| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
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| Ligand | BDBM50262016 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961931 (CHEMBL2390522) |
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| IC50 | 57±n/a nM |
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| Citation |  Engers, DW; Frist, AY; Lindsley, CW; Hong, CC; Hopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett23:3248-52 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1B |
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| Name: | Bone morphogenetic protein receptor type-1B |
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| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56939.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00238 |
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| Residue: | 502 |
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| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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| BDBM50262016 |
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| n/a |
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| Name | BDBM50262016 |
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| Synonyms: | 4-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | CHEMBL511563 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16N4O |
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| Mol. Mass. | 352.3886 |
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| SMILES | COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |
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| Structure | 
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