| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase subunit beta-1 |
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| Ligand | BDBM102618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961928 (CHEMBL2390519) |
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| IC50 | 2520±n/a nM |
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| Citation |  Engers, DW; Frist, AY; Lindsley, CW; Hong, CC; Hopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett23:3248-52 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase subunit beta-1 |
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| Name: | 5'-AMP-activated protein kinase subunit beta-1 |
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| Synonyms: | 5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1 |
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| Type: | n/a |
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| Mol. Mass.: | 30380.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y478 |
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| Residue: | 270 |
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| Sequence: | MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI
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| BDBM102618 |
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| n/a |
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| Name | BDBM102618 |
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| Synonyms: | LDN-212854 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6 |
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| Mol. Mass. | 406.4824 |
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| SMILES | C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |
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| Structure | 
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