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TargetActivin receptor type-1B
LigandBDBM50434752
Substrate/Competitorn/a
Meas. Tech.ChEMBL_961932 (CHEMBL2390523)
IC50 326±n/a nM
Citation Engers, DWFrist, AYLindsley, CWHong, CCHopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett23:3248-52 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Activin receptor type-1B
Name:Activin receptor type-1B
Synonyms:ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4)
Type:PROTEIN
Mol. Mass.:56810.99
Organism:Homo sapiens (Human)
Description:ChEMBL_587064
Residue:505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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  Blast E-value cutoff:
BDBM50434752
n/a
NameBDBM50434752
Synonyms:CHEMBL2385582
TypeSmall organic molecule
Emp. Form.C25H21N5O
Mol. Mass.407.4671
SMILESC1CN(CCO1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Structure
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