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TargetBone morphogenetic protein receptor type-1B
LigandBDBM50434749
Substrate/Competitorn/a
Meas. Tech.ChEMBL_961931 (CHEMBL2390522)
IC50 129±n/a nM
Citation Engers, DWFrist, AYLindsley, CWHong, CCHopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett23:3248-52 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bone morphogenetic protein receptor type-1B
Name:Bone morphogenetic protein receptor type-1B
Synonyms:ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B)
Type:Enzyme
Mol. Mass.:56939.41
Organism:Homo sapiens (Human)
Description:O00238
Residue:502
Sequence:
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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  Blast E-value cutoff:
BDBM50434749
n/a
NameBDBM50434749
Synonyms:CHEMBL2385586
TypeSmall organic molecule
Emp. Form.C19H19N7
Mol. Mass.345.4011
SMILESC1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1
Structure
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