| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
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| Ligand | BDBM50262685 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961935 (CHEMBL2390526) |
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| IC50 | 106±n/a nM |
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| Citation |  Engers, DW; Frist, AY; Lindsley, CW; Hong, CC; Hopkins, CR Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett23:3248-52 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase receptor R3 |
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| Name: | Serine/threonine-protein kinase receptor R3 |
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| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56134.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37023 |
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| Residue: | 503 |
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| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
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| BDBM50262685 |
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| n/a |
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| Name | BDBM50262685 |
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| Synonyms: | 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | CHEMBL478629 | Dorsomorphin | US9040694, Dorsomorphin |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O |
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| Mol. Mass. | 399.4882 |
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| SMILES | C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1 |
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| Structure | 
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