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TargetIleal sodium/bile acid cotransporter
LigandBDBM50134411
Substrate/Competitorn/a
Meas. Tech.ChEMBL_963356
IC50 3.0±n/a nM
Citation Wu YAquino CJCowan DJAnderson DLAmbroso JLBishop MJBoros EEChen LCunningham ADobbins RLFeldman PLHarston LTKaldor IWKlein RLiang XMcIntyre MSMerrill CLPatterson KMPrescott JSRay JSRoller SGYao XYoung AYuen JCollins JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem 56:5094-114 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ileal sodium/bile acid cotransporter
Name:Ileal sodium/bile acid cotransporter
Synonyms:ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | Na(+)-dependent ileal bile acid transporter | Ntcp2 | Slc10a2 | Sodium/taurocholate cotransporting polypeptide, ileal | Solute carrier family 10 member 2
Type:PROTEIN
Mol. Mass.:38130.25
Organism:Mus musculus
Description:ChEMBL_963356
Residue:348
Sequence:
MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAMVMFSMGCNVEVHKFLG
HIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWID
GDMDLSVSMTTCSTLLALGMMPLCLFVYTKMWVDSGTIVIPYDSIGISLVALVIPVSFGM
FVNHKWPQKAKIILKIGSITGVILIVLIAVIGGILYQSAWIIEPKLWIIGTIFPIAGYSL
GFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVF
AAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRPSFDETNKGFQPDEK
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BDBM50134411
n/a
NameBDBM50134411
Synonyms:(7R,9R)-7-Butyl-7-ethyl-2,3-dimethoxy-9-phenyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocycloheptene 5,5-dioxide | CHEMBL332370
TypeSmall organic molecule
Emp. Form.C23H31NO4S
Mol. Mass.417.562
SMILESCCCC[C@]1(CC)CS(=O)(=O)c2cc(OC)c(OC)cc2[C@H](N1)c1ccccc1
Structure
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