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TargetIleal sodium/bile acid cotransporter
LigandBDBM50434849
Substrate/Competitorn/a
Meas. Tech.ChEMBL_963355
IC50 0.900000±n/a nM
Citation Wu YAquino CJCowan DJAnderson DLAmbroso JLBishop MJBoros EEChen LCunningham ADobbins RLFeldman PLHarston LTKaldor IWKlein RLiang XMcIntyre MSMerrill CLPatterson KMPrescott JSRay JSRoller SGYao XYoung AYuen JCollins JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem 56:5094-114 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ileal sodium/bile acid cotransporter
Name:Ileal sodium/bile acid cotransporter
Synonyms:ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | Na(+)-dependent ileal bile acid transporter | Ntcp2 | Slc10a2 | Sodium/taurocholate-cotransporting polypeptide, ileal | Solute carrier family 10 member 2
Type:PROTEIN
Mol. Mass.:38020.22
Organism:Rattus norvegicus
Description:ChEMBL_104627
Residue:348
Sequence:
MDNSSVCSPNATFCEGDSCLVTESNFNAILSTVMSTVLTILLAMVMFSMGCNVEINKFLG
HIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWID
GDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSGTIVIPYDSIGISLVALVIPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIEPKLWIIGTIFPIAGYSL
GFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVF
AAIILGMYVTYKKCHGKNDAEFLEKTDNDMDPMPSFQETNKGFQPDEK
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  Blast E-value cutoff:
BDBM50434849
n/a
NameBDBM50434849
Synonyms:CHEMBL2385105 | US9040518, 6
TypeSmall organic molecule
Emp. Form.C23H32NO6PS
Mol. Mass.481.542
SMILESCCCC[C@]1(CC)CS(=O)(=O)c2cc(CP(O)(O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r|
Structure
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