| Reaction Details |
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 | Report a problem with these data |
| Target | Ileal sodium/bile acid cotransporter |
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| Ligand | BDBM50134411 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_963355 (CHEMBL2388852) |
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| IC50 | 22±n/a nM |
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| Citation |  Wu, Y; Aquino, CJ; Cowan, DJ; Anderson, DL; Ambroso, JL; Bishop, MJ; Boros, EE; Chen, L; Cunningham, A; Dobbins, RL; Feldman, PL; Harston, LT; Kaldor, IW; Klein, R; Liang, X; McIntyre, MS; Merrill, CL; Patterson, KM; Prescott, JS; Ray, JS; Roller, SG; Yao, X; Young, A; Yuen, J; Collins, JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem56:5094-114 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ileal sodium/bile acid cotransporter |
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| Name: | Ileal sodium/bile acid cotransporter |
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| Synonyms: | ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2_RAT | Na(+)-dependent ileal bile acid transporter | Ntcp2 | Slc10a2 | Sodium/taurocholate-cotransporting polypeptide, ileal | Solute carrier family 10 member 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38020.22 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104627 |
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| Residue: | 348 |
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| Sequence: | MDNSSVCSPNATFCEGDSCLVTESNFNAILSTVMSTVLTILLAMVMFSMGCNVEINKFLG
HIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWID
GDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSGTIVIPYDSIGISLVALVIPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIEPKLWIIGTIFPIAGYSL
GFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVF
AAIILGMYVTYKKCHGKNDAEFLEKTDNDMDPMPSFQETNKGFQPDEK
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| BDBM50134411 |
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| n/a |
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| Name | BDBM50134411 |
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| Synonyms: | (7R,9R)-7-Butyl-7-ethyl-2,3-dimethoxy-9-phenyl-6,7,8,9-tetrahydro-5-thia-8-aza-benzocycloheptene 5,5-dioxide | CHEMBL332370 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31NO4S |
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| Mol. Mass. | 417.562 |
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| SMILES | CCCC[C@]1(CC)CS(=O)(=O)c2cc(OC)c(OC)cc2[C@H](N1)c1ccccc1 |
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| Structure | 
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