| Reaction Details |
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 | Report a problem with these data |
| Target | Ileal sodium/bile acid cotransporter |
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| Ligand | BDBM50434865 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_963360 (CHEMBL2388857) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Wu, Y; Aquino, CJ; Cowan, DJ; Anderson, DL; Ambroso, JL; Bishop, MJ; Boros, EE; Chen, L; Cunningham, A; Dobbins, RL; Feldman, PL; Harston, LT; Kaldor, IW; Klein, R; Liang, X; McIntyre, MS; Merrill, CL; Patterson, KM; Prescott, JS; Ray, JS; Roller, SG; Yao, X; Young, A; Yuen, J; Collins, JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem56:5094-114 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ileal sodium/bile acid cotransporter |
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| Name: | Ileal sodium/bile acid cotransporter |
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| Synonyms: | ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37714.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | SLC10A2 |
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| Residue: | 348 |
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| Sequence: | MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
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| BDBM50434865 |
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| n/a |
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| Name | BDBM50434865 |
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| Synonyms: | CHEMBL2387511 | US9040518, 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N2O7S2 |
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| Mol. Mass. | 538.677 |
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| SMILES | CCCC[C@]1(CC)CS(=O)(=O)c2cc(CNC(=O)CS(O)(=O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r| |
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| Structure | 
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