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TargetIleal bile acid transporter/bile acid cotransporter
LigandBDBM50434867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_963360
IC50 4.0±n/a nM
Citation Wu YAquino CJCowan DJAnderson DLAmbroso JLBishop MJBoros EEChen LCunningham ADobbins RLFeldman PLHarston LTKaldor IWKlein RLiang XMcIntyre MSMerrill CLPatterson KMPrescott JSRay JSRoller SGYao XYoung AYuen JCollins JL Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem 56:5094-114 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ileal bile acid transporter/bile acid cotransporter
Name:Ileal bile acid transporter/bile acid cotransporter
Synonyms:ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal sodium-dependent bile acid transporter
Type:Enzyme
Mol. Mass.:37714.89
Organism:Homo sapiens (Human)
Description:SLC10A2
Residue:348
Sequence:
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
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  Blast E-value cutoff:
BDBM50434867
n/a
NameBDBM50434867
Synonyms:CHEMBL2387522 | US9040518, 20
TypeSmall organic molecule
Emp. Form.C25H35NO6S2
Mol. Mass.509.679
SMILESCCCC[C@]1(CC)CS(=O)(=O)c2cc(CCCS(O)(=O)=O)c(OC)cc2[C@H](N1)c1ccccc1 |r|
Structure
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