Reaction Details |
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Target | Quinolone resistance protein NorA |
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Ligand | BDBM50434967 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_961221 (CHEMBL2390113) |
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IC50 | 8500±n/a nM |
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Citation | Sabatini, S; Gosetto, F; Iraci, N; Barreca, ML; Massari, S; Sancineto, L; Manfroni, G; Tabarrini, O; Dimovska, M; Kaatz, GW; Cecchetti, V Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance. J Med Chem56:4975-89 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Quinolone resistance protein NorA |
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Name: | Quinolone resistance protein NorA |
Synonyms: | NORA_STAAU | norA |
Type: | PROTEIN |
Mol. Mass.: | 42273.03 |
Organism: | Staphylococcus aureus |
Description: | ChEMBL_961221 |
Residue: | 388 |
Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
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BDBM50434967 |
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n/a |
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Name | BDBM50434967 |
Synonyms: | CHEMBL2385667 |
Type | Small organic molecule |
Emp. Form. | C27H32N2O4 |
Mol. Mass. | 448.554 |
SMILES | CCCOc1ccc(cc1)-c1cc(OCCN2CCC3(CC2)OCCO3)c2ccccc2n1 |
Structure |
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