| Reaction Details |
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 | Report a problem with these data |
| Target | Quinolone resistance protein NorA |
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| Ligand | BDBM50434973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961221 (CHEMBL2390113) |
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| IC50 | 3900±n/a nM |
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| Citation |  Sabatini, S; Gosetto, F; Iraci, N; Barreca, ML; Massari, S; Sancineto, L; Manfroni, G; Tabarrini, O; Dimovska, M; Kaatz, GW; Cecchetti, V Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance. J Med Chem56:4975-89 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Quinolone resistance protein NorA |
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| Name: | Quinolone resistance protein NorA |
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| Synonyms: | NORA_STAAU | norA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42273.03 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_961221 |
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| Residue: | 388 |
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| Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
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| BDBM50434973 |
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| n/a |
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| Name | BDBM50434973 |
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| Synonyms: | CHEMBL2385681 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N2O2 |
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| Mol. Mass. | 364.4806 |
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| SMILES | CCCOc1ccc(cc1)-c1cc(OCCCN(C)C)c2ccccc2n1 |
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| Structure | 
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