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TargetProstaglandin E synthase
LigandBDBM50435045
Substrate/Competitorn/a
Meas. Tech.ChEMBL_964546
IC50 3.0±n/a nM
Citation Arhancet GBWalker DPMetz SFobian YMHeasley SECarter JSSpringer JRJones DEHayes MJShaffer AFJerome GMBaratta MTZweifel BMoore WMMasferrer JLVazquez ML Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett 23:1114-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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BDBM50435045
n/a
NameBDBM50435045
Synonyms:CHEMBL2391141
TypeSmall organic molecule
Emp. Form.C28H34ClN3O4
Mol. Mass.512.04
SMILESCCOc1ccc(cc1)-c1cc2oc(nc2cc1Cl)N1CCC(CC1)C(=O)N[C@H]1CCC[C@H](CO)C1 |r|
Structure
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