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TargetProstaglandin E synthase
LigandBDBM50435048
Substrate/Competitorn/a
Meas. Tech.ChEMBL_964546 (CHEMBL2393934)
IC50 2.0±n/a nM
Citation Arhancet, GBWalker, DPMetz, SFobian, YMHeasley, SECarter, JSSpringer, JRJones, DEHayes, MJShaffer, AFJerome, GMBaratta, MTZweifel, BMoore, WMMasferrer, JLVazquez, ML Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett23:1114-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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  Blast E-value cutoff:
BDBM50435048
n/a
NameBDBM50435048
Synonyms:CHEMBL2391142
TypeSmall organic molecule
Emp. Form.C27H29ClF3N3O4
Mol. Mass.551.985
SMILESOC[C@H]1CCC[C@@H](C1)NC(=O)C1CCN(CC1)c1nc2cc(Cl)c(cc2o1)-c1ccc(OC(F)(F)F)cc1 |r|
Structure
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