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TargetMethionine Aminopeptidase Type 1 (MetAP1)
LigandBDBM50435190
Substrate/Competitorn/a
Meas. Tech.ChEMBL_963503
EC50 520±n/a nM
Citation Zhang PYang XZhang FGabelli SBWang RZhang YBhat SChen XFurlani MAmzel LMLiu JOMa D Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem 21:2600-17 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine Aminopeptidase Type 1 (MetAP1)
Name:Aminopeptidase
Synonyms:MAP 1 | MetAP 1 | Peptidase M 1
Type:Enzyme
Mol. Mass.:43220.79
Organism:Homo sapiens (Human)
Description:MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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  Blast E-value cutoff:
BDBM50435190
n/a
NameBDBM50435190
Synonyms:CHEMBL2392926
TypeSmall organic molecule
Emp. Form.C29H28Cl2N6
Mol. Mass.531.479
SMILESCc1nc(nc(NC[C@H](NCCCCc2ccc(cc2)C#N)c2ccccc2)c1Cl)-c1ccc(Cl)cn1 |r|
Structure
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