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TargetMethionine aminopeptidase 1
LigandBDBM50435229
Substrate/Competitorn/a
Meas. Tech.ChEMBL_963503 (CHEMBL2394384)
IC50 1000±n/a nM
Citation Zhang, PYang, XZhang, FGabelli, SBWang, RZhang, YBhat, SChen, XFurlani, MAmzel, LMLiu, JOMa, D Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem21:2600-17 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine aminopeptidase 1
Name:Methionine aminopeptidase 1
Synonyms:Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:Enzyme
Mol. Mass.:43220.79
Organism:Homo sapiens (Human)
Description:MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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  Blast E-value cutoff:
BDBM50435229
n/a
NameBDBM50435229
Synonyms:CHEMBL2392771
TypeSmall organic molecule
Emp. Form.C18H16ClF3N6
Mol. Mass.408.808
SMILESCc1nc(nc(NCCNc2cccc(n2)C(F)(F)F)c1Cl)-c1ccccn1
Structure
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