| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4/beta-4 |
|---|
| Ligand | BDBM50014210 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_964974 (CHEMBL2396007) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Arunotayanun, W; Dalley, JW; Huang, XP; Setola, V; Treble, R; Iversen, L; Roth, BL; Gibbons, S An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorg Med Chem Lett23:3411-5 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-4/beta-4 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-4/beta-4 |
|---|
| Synonyms: | Neuronal acetylcholine receptor protein alpha-4/beta-4 subunit | Neuronal acetylcholine receptor; alpha4/beta4 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 143890 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit beta-4 |
|---|
| Synonyms: | ACHB4_HUMAN | CHRNB4 | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 | Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 | Nicotinic acetylcholine receptor alpha6/alpha3/beta4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 56388.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 0 HUMAN::P30926 |
|---|
| Residue: | 498 |
|---|
| Sequence: | MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL
SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN
ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE
IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI
IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM
FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF
PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF
RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP
PLFQTHAASEGPYAAQRD
|
|
|
|---|
| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Synonyms: | ACHA4_HUMAN | CHRNA4 | CHRNA4 protein | NACRA4 | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Nicotinic acetylcholine receptor alpha4/beta2/alpha5 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 69963.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | NACHRA4 |
|---|
| Residue: | 627 |
|---|
| Sequence: | MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD
VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR
RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS
LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR
PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP
SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG
GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV
SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR
IFLWMFIIVCLLGTVGLFLPPWLAGMI
|
|
|
|---|
| BDBM50014210 |
|---|
| n/a |
|---|
| Name | BDBM50014210 |
|---|
| Synonyms: | 1-(1H-Indol-3-yl)-2-propanamine | 1-(1H-indol-3-yl)propan-2-amine | 3-(2-Aminopropyl)indole | CHEMBL30713 | DL-3-(2-Aminopropyl)indole | Indopan | alpha-Methyl-1H-indole-3-ethanamine | alpha-Methyl-3-indoleethanamine | alpha-Methyl-beta-indoleethylamine | alpha-methyltryptamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H14N2 |
|---|
| Mol. Mass. | 174.2423 |
|---|
| SMILES | CC(N)Cc1c[nH]c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
