| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM50435546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_966260 (CHEMBL2395921) |
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| IC50 | 381±n/a nM |
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| Citation |  Tran, PT; Hoang, VH; Thorat, SA; Kim, SE; Ann, J; Chang, YJ; Nam, DW; Song, H; Mook-Jung, I; Lee, J; Lee, J Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template. Bioorg Med Chem21:3821-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM50435546 |
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| n/a |
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| Name | BDBM50435546 |
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| Synonyms: | CHEMBL2392804 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18N6S |
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| Mol. Mass. | 314.409 |
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| SMILES | Cc1cncn1CCCNC(=S)Nc1ccc2cn[nH]c2c1 |
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| Structure | 
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