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TargetGlutaminyl Cyclase
LigandBDBM50435547
Substrate/Competitorn/a
Meas. Tech.ChEMBL_966260
IC50 239±n/a nM
Citation Tran PTHoang VHThorat SAKim SEAnn JChang YJNam DWSong HMook-Jung ILee JLee J Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template. Bioorg Med Chem 21:3821-30 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glutaminyl Cyclase
Name:Glutaminyl-peptide cyclotransferase
Synonyms:Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC)
Type:Enzyme
Mol. Mass.:40877.05
Organism:Homo sapiens (Human)
Description:Q16769
Residue:361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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BDBM50435547
n/a
NameBDBM50435547
Synonyms:CHEMBL2392803
TypeSmall organic molecule
Emp. Form.C16H20N6S
Mol. Mass.328.435
SMILESCc1cncn1CCCNC(=S)Nc1ccc2cnn(C)c2c1
Structure
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