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Target11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
LigandBDBM50435691
Substrate/Competitorn/a
Meas. Tech.ChEMBL_965016
Ki 7.0±n/a nM
Citation Bauman DRWhitehead AContino LCCui JGarcia-Calvo MGu XKevin NMa XPai LYShah KShen XStribling SZokian HJMetzger JShevell DEWaddell ST Evaluation of selective inhibitors of 11-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett 23:3650-3 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
Name:11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1)
Type:Enzyme
Mol. Mass.:31889.48
Organism:Rattus norvegicus (rat)
Description:P16232
Residue:288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
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  Blast E-value cutoff:
BDBM50435691
n/a
NameBDBM50435691
Synonyms:CHEMBL2391968
TypeSmall organic molecule
Emp. Form.C22H22F5N5O
Mol. Mass.467.435
SMILESCn1c(nnc1C12CCC(CC1)(CC2)c1noc(n1)C(C)(F)F)-c1ccccc1C(F)(F)F
Structure
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