Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50435691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_965016 (CHEMBL2396178) |
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IC50 | 4.5±n/a nM |
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Citation | Bauman, DR; Whitehead, A; Contino, LC; Cui, J; Garcia-Calvo, M; Gu, X; Kevin, N; Ma, X; Pai, LY; Shah, K; Shen, X; Stribling, S; Zokian, HJ; Metzger, J; Shevell, DE; Waddell, ST Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett23:3650-3 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1 |
Type: | Enzyme |
Mol. Mass.: | 31889.48 |
Organism: | Rattus norvegicus (rat) |
Description: | P16232 |
Residue: | 288 |
Sequence: | MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
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BDBM50435691 |
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n/a |
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Name | BDBM50435691 |
Synonyms: | CHEMBL2391968 |
Type | Small organic molecule |
Emp. Form. | C22H22F5N5O |
Mol. Mass. | 467.435 |
SMILES | Cn1c(nnc1C12CCC(CC1)(CC2)c1noc(n1)C(C)(F)F)-c1ccccc1C(F)(F)F |
Structure |
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