Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 7 |
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Ligand | BDBM50436152 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_968437 (CHEMBL2400588) |
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IC50 | 3800±n/a nM |
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Citation | Yamaguchi, M; Miyazaki, M; Kodrasov, MP; Rotinsulu, H; Losung, F; Mangindaan, RE; de Voogd, NJ; Yokosawa, H; Nicholson, B; Tsukamoto, S Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor. Bioorg Med Chem Lett23:3884-6 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 7 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
Synonyms: | Deubiquitinating enzyme 7 | HAUSP | Herpesvirus-associated ubiquitin-specific protease | UBP7_HUMAN | USP7 | Ubiquitin thioesterase 7 | Ubiquitin-specific-processing protease 7 |
Type: | PROTEIN |
Mol. Mass.: | 128274.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469483 |
Residue: | 1102 |
Sequence: | MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDME
DDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQ
CNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPE
KGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRK
AVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELC
RVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNI
FESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIK
INDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKF
DDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQL
VERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNS
SLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTI
FLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVM
CDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSEL
PTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFF
KSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLN
SQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLE
CLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREV
MKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLD
HFNKAPKRSRYTYLEKAIKIHN
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BDBM50436152 |
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n/a |
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Name | BDBM50436152 |
Synonyms: | SPONGIACIDIN C |
Type | Small organic molecule |
Emp. Form. | C11H10N4O3 |
Mol. Mass. | 246.2221 |
SMILES | O=C1NC(=O)\C(N1)=C1/CCNC(=O)c2[nH]ccc12 |
Structure |
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