| Reaction Details |
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 | Report a problem with these data |
| Target | Transforming protein RhoA |
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| Ligand | BDBM50436255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_966397 (CHEMBL2398834) |
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| IC50 | 6100±n/a nM |
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| Citation |  Bell, JL; Haak, AJ; Wade, SM; Kirchhoff, PD; Neubig, RR; Larsen, SD Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett23:3826-32 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transforming protein RhoA |
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| Name: | Transforming protein RhoA |
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| Synonyms: | ARH12 | ARHA | RHO12 | RHOA | RHOA_HUMAN | Rho cDNA clone 12 | h12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21766.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_966397 |
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| Residue: | 193 |
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| Sequence: | MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD
LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ
ARRGKKKSGCLVL
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| BDBM50436255 |
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| n/a |
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| Name | BDBM50436255 |
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| Synonyms: | CHEMBL2398701 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21F6N3O2S |
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| Mol. Mass. | 541.509 |
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| SMILES | Cc1nc(cs1)-c1cccc(NC(=O)C2CCCN(C2)C(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 |
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| Structure | 
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