| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50436307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_966433 (CHEMBL2399021) |
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| IC50 | 1.8±n/a nM |
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| Citation |  Gardner, DS; Santella, JB; Duncia, JV; Carter, PH; Dhar, TG; Wu, H; Guo, W; Cavallaro, C; Van Kirk, K; Yarde, M; Briceno, SW; Grafstrom, RR; Liu, R; Patel, SR; Tebben, AJ; Camac, D; Khan, J; Watson, A; Yang, G; Rose, A; Foster, WR; Cvijic, ME; Davies, P; Hynes, J The discovery of BMS-457, a potent and selective CCR1 antagonist. Bioorg Med Chem Lett23:3833-40 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50436307 |
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| n/a |
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| Name | BDBM50436307 |
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| Synonyms: | CHEMBL2398746 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H33ClN2O3 |
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| Mol. Mass. | 420.973 |
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| SMILES | CC(C)[C@@H](NC(=O)C1CCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 |r| |
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| Structure | 
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