| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
|---|
| Ligand | BDBM50436282 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_966433 (CHEMBL2399021) |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Citation |  Gardner, DS; Santella, JB; Duncia, JV; Carter, PH; Dhar, TG; Wu, H; Guo, W; Cavallaro, C; Van Kirk, K; Yarde, M; Briceno, SW; Grafstrom, RR; Liu, R; Patel, SR; Tebben, AJ; Camac, D; Khan, J; Watson, A; Yang, G; Rose, A; Foster, WR; Cvijic, ME; Davies, P; Hynes, J The discovery of BMS-457, a potent and selective CCR1 antagonist. Bioorg Med Chem Lett23:3833-40 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 1 |
|---|
| Name: | C-C chemokine receptor type 1 |
|---|
| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41180.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P32246 |
|---|
| Residue: | 355 |
|---|
| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
|
|
|
|---|
| BDBM50436282 |
|---|
| n/a |
|---|
| Name | BDBM50436282 |
|---|
| Synonyms: | CHEMBL2398769 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32ClN3O3 |
|---|
| Mol. Mass. | 457.993 |
|---|
| SMILES | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
