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TargetApoptosis regulator Bcl-2
LigandBDBM21447
Substrate/Competitorn/a
Meas. Tech.ChEMBL_967614
IC50 7.0±n/a nM
Citation Sleebs BEKersten WJKulasegaram SNikolakopoulos GHatzis EMoss RMParisot JPYang HCzabotar PEFairlie WDLee EFAdams JMChen Lvan Delft MFLowes KNWei AHuang DCColman PMStreet IPBaell JBWatson KLessene G Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem 56:5514-40 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM21447
n/a
NameBDBM21447
Synonyms:4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide | ABT-737 | CHEMBL376408 | N-Benylpiperazine derivative, 2 | US9125913, ABT-737
TypeSmall organic molecule
Emp. Form.C42H45ClN6O5S2
Mol. Mass.813.427
SMILESCN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r|
Structure
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