| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM50436706 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_966729 (CHEMBL2400289) |
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| IC50 | 141±n/a nM |
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| Citation |  Shiao, HY; Coumar, MS; Chang, CW; Ke, YY; Chi, YH; Chu, CY; Sun, HY; Chen, CH; Lin, WH; Fung, KS; Kuo, PC; Huang, CT; Chang, KY; Lu, CT; Hsu, JT; Chen, CT; Jiaang, WT; Chao, YS; Hsieh, HP Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor. J Med Chem56:5247-60 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM50436706 |
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| n/a |
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| Name | BDBM50436706 |
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| Synonyms: | CHEMBL2398652 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H33N5O2 |
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| Mol. Mass. | 531.6474 |
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| SMILES | O=C(NC1CCCCC1)Nc1ccc(CCNc2ncnc3oc(c(-c4ccccc4)c23)-c2ccccc2)cc1 |
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| Structure | 
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