| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Ligand | BDBM92347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_970148 (CHEMBL2406233) |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Citation |  Richters, A; Ketzer, J; Getlik, M; Grütter, C; Schneider, R; Heuckmann, JM; Heynck, S; Sos, ML; Gupta, A; Unger, A; Schultz-Fademrecht, C; Thomas, RK; Bauer, S; Rauh, D Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design. J Med Chem56:5757-72 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proto-oncogene tyrosine-protein kinase Src |
|---|
| Name: | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Synonyms: | Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src |
|---|
| Type: | Tyr protein kinase |
|---|
| Mol. Mass.: | 60015.36 |
|---|
| Organism: | Gallus gallus (Chicken) |
|---|
| Description: | P00523 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL
FGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL
AHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR
LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG
TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ
GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
|
|
|
|---|
| BDBM92347 |
|---|
| n/a |
|---|
| Name | BDBM92347 |
|---|
| Synonyms: | 1,4-Hybrid, 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H33N9O2 |
|---|
| Mol. Mass. | 563.6528 |
|---|
| SMILES | CCC(=O)Nc1ccc2ncnc(Nc3ccc(NC(=O)Nc4cc(nn4-c4cccc(N)c4)C(C)(C)C)cc3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
