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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50437383
Substrate/Competitorn/a
Meas. Tech.ChEMBL_972632 (CHEMBL2410612)
IC50 4.6±n/a nM
Citation He, SHong, QLai, ZWu, ZYu, YKim, DWTing, PCKuethe, JTYang, GXJian, TLiu, JGuiadeen, DKrikorian, ADSperbeck, DMSonatore, LMWiltsie, JChung, CCGibson, JTLisnock, JMurphy, BAGorski, JNLiu, JChen, DChen, XWolff, MTong, SXMadeira, MKaranam, BVShen, DMBalkovec, JMPinto, SNargund, RPDeVita, RJ Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety. ACS Med Chem Lett4:773-8 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Enzyme
Mol. Mass.:56810.61
Organism:Mus musculus (mouse)
Description:In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system.
Residue:498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTR
DKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKY
GILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVN
LATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTG
KKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFT
QLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAV
AELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFL
TSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAV
LMYVHDYYVLNYDAPVGV
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  Blast E-value cutoff:
BDBM50437383
n/a
NameBDBM50437383
Synonyms:CHEMBL2408623
TypeSmall organic molecule
Emp. Form.C25H21F3N4O4
Mol. Mass.498.4538
SMILESOC(=O)[C@@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cn1)-c1nc2ccc(OC(F)(F)F)cc2[nH]1 |r,wU:6.9,3.2,(19.56,-40.23,;20.34,-38.9,;21.88,-38.9,;19.56,-37.56,;20.33,-36.23,;19.56,-34.89,;18.03,-34.91,;17.25,-36.23,;18.02,-37.56,;17.26,-33.57,;15.72,-33.58,;14.94,-32.24,;13.4,-32.25,;12.64,-33.58,;13.41,-34.92,;14.95,-34.91,;11.1,-33.58,;10.32,-32.24,;8.79,-32.25,;8.02,-33.58,;8.79,-34.91,;10.33,-34.91,;6.49,-33.58,;5.58,-34.82,;4.11,-34.35,;2.78,-35.11,;1.45,-34.35,;1.45,-32.81,;.12,-32.04,;.11,-30.5,;-1.22,-29.73,;1.45,-29.73,;.1,-28.96,;2.78,-32.03,;4.11,-32.81,;5.58,-32.33,)|
Structure
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