| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase HCK |
|---|
| Ligand | BDBM50437405 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_972650 (CHEMBL2410630) |
|---|
| Ki | 504±n/a nM |
|---|
| Citation |  Ko, KS; Steffey, ME; Brandvold, KR; Soellner, MB Development of a chimeric c-Src kinase and HDAC inhibitor. ACS Med Chem Lett4:779-783 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase HCK |
|---|
| Name: | Tyrosine-protein kinase HCK |
|---|
| Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 59600.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08631 |
|---|
| Residue: | 526 |
|---|
| Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
|
|
|
|---|
| BDBM50437405 |
|---|
| n/a |
|---|
| Name | BDBM50437405 |
|---|
| Synonyms: | CHEMBL2408778 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24ClN9O2 |
|---|
| Mol. Mass. | 517.97 |
|---|
| SMILES | Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1CCCCCC(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
