| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Ligand | BDBM50437464 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_974577 (CHEMBL2410165) |
|---|
| IC50 | 491±n/a nM |
|---|
| Citation |  Wang, QQ; Cheng, N; Zheng, XW; Peng, SM; Zou, XQ Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Bioorg Med Chem21:4301-10 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35916.27 |
|---|
| Organism: | Bos taurus (Cattle) |
|---|
| Description: | P16116[K65Q] |
|---|
| Residue: | 315 |
|---|
| Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
|
|
|
|---|
| BDBM50437464 |
|---|
| n/a |
|---|
| Name | BDBM50437464 |
|---|
| Synonyms: | CHEMBL2409461 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21NO11 |
|---|
| Mol. Mass. | 487.4129 |
|---|
| SMILES | [O-]c1cc(oc2cc(OCC(=O)OCCCCO[N+]([O-])=O)cc(=[OH+])c12)-c1ccc2OCCOc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
