| Reaction Details |
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 | Report a problem with these data |
| Target | Vesicular acetylcholine transporter |
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| Ligand | BDBM50292907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_973123 (CHEMBL2412886) |
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| Ki | 2.7±n/a nM |
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| Citation |  Li, J; Zhang, X; Zhang, Z; Padakanti, PK; Jin, H; Cui, J; Li, A; Zeng, D; Rath, NP; Flores, H; Perlmutter, JS; Parsons, SM; Tu, Z Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter. J Med Chem56:6216-33 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vesicular acetylcholine transporter |
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| Name: | Vesicular acetylcholine transporter |
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| Synonyms: | SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56900.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1507628 |
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| Residue: | 532 |
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| Sequence: | MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDY
IAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESE
DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFA
ARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAG
KRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTT
CNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYG
ALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSV
YAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRS
ERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
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| BDBM50292907 |
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| n/a |
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| Name | BDBM50292907 |
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| Synonyms: | (+)-trans-(4-fluorophenyl)(1-(3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)methanone | (+/-)-trans-2-Hydroxy-3-(4-(4-fluorobenzoyl)piperidino)tetralin | (-)-trans(4-fluorophenyl)(1-(3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)methanone | CHEMBL473129 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24FNO2 |
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| Mol. Mass. | 353.4299 |
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| SMILES | O[C@@H]1Cc2ccccc2C[C@H]1N1CCC(CC1)C(=O)c1ccc(F)cc1 |r| |
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| Structure | 
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