| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50437790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_973504 (CHEMBL2410678) |
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| IC50 | 8.9±n/a nM |
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| Citation |  De Savi, C; Waterson, D; Pape, A; Lamont, S; Hadley, E; Mills, M; Page, KM; Bowyer, J; Maciewicz, RA Hydantoin based inhibitors of MMP13--discovery of AZD6605. Bioorg Med Chem Lett23:4705-12 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50437790 |
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| n/a |
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| Name | BDBM50437790 |
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| Synonyms: | CHEMBL2409711 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20ClN3O5S |
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| Mol. Mass. | 401.865 |
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| SMILES | C[C@]1(CS(=O)(=O)N2CCC(CC2)Oc2ccc(Cl)cc2)NC(=O)NC1=O |r| |
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| Structure | 
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