| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM50437928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972806 (CHEMBL2411274) |
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| Ki | 38000±n/a nM |
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| Citation |  al-Rashida, M; Raza, R; Abbas, G; Shah, MS; Kostakis, GE; Lecka, J; Sévigny, J; Muddassar, M; Papatriantafyllopoulou, C; Iqbal, J Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases. Eur J Med Chem66:438-49 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP) |
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| Type: | Protein |
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| Mol. Mass.: | 57195.60 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P09487 |
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| Residue: | 524 |
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| Sequence: | MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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| BDBM50437928 |
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| n/a |
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| Name | BDBM50437928 |
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| Synonyms: | CHEMBL2408697 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N4O6S |
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| Mol. Mass. | 482.509 |
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| SMILES | CCOC1Oc2ccccc2C(=O)C1=CNc1ccc(cc1)S(=O)(=O)Nc1ccc(OC)nn1 |w:14.16| |
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| Structure | 
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