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TargetAlkaline phosphatase, tissue-nonspecific isozyme
LigandBDBM50437936
Substrate/Competitorn/a
Meas. Tech.ChEMBL_972806 (CHEMBL2411274)
Ki 43000±n/a nM
Citation al-Rashida, MRaza, RAbbas, GShah, MSKostakis, GELecka, JSévigny, JMuddassar, MPapatriantafyllopoulou, CIqbal, J Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases. Eur J Med Chem66:438-49 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase, tissue-nonspecific isozyme
Name:Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:Protein
Mol. Mass.:57195.60
Organism:Bos taurus (Cattle)
Description:P09487
Residue:524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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  Blast E-value cutoff:
BDBM50437936
n/a
NameBDBM50437936
Synonyms:CHEMBL2408700
TypeSmall organic molecule
Emp. Form.C16H11FN2O4S
Mol. Mass.346.333
SMILESFc1ccc2occ(C3Nc4ccccc4S(=O)(=O)N3)c(=O)c2c1
Structure
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