| Reaction Details |
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 | Report a problem with these data |
| Target | Papain |
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| Ligand | BDBM50157741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972846 (CHEMBL2411623) |
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| Ki | 5080±n/a nM |
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| Citation |  Schiefer, IT; Tapadar, S; Litosh, V; Siklos, M; Scism, R; Wijewickrama, GT; Chandrasena, EP; Sinha, V; Tavassoli, E; Brunsteiner, M; Fa', M; Arancio, O; Petukhov, P; Thatcher, GR Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. J Med Chem56:6054-68 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Papain |
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| Name: | Papain |
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| Synonyms: | Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I |
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| Type: | Enzyme |
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| Mol. Mass.: | 38923.01 |
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| Organism: | Carica papaya |
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| Description: | Papain was purchased from Sigma, Germany. |
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| Residue: | 345 |
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| Sequence: | MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYK
NIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTE
LSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNE
YSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKT
DGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYG
PNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
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| BDBM50157741 |
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| n/a |
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| Name | BDBM50157741 |
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| Synonyms: | CHEMBL374508 | E-64 | E64 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27N5O5 |
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| Mol. Mass. | 357.4054 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r| |
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| Structure | 
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