| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
|---|
| Ligand | BDBM50438143 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_972975 (CHEMBL2412213) |
|---|
| IC50 | 70±n/a nM |
|---|
| Citation |  Gustin, DJ; Li, Y; Brown, ML; Min, X; Schmitt, MJ; Wanska, M; Wang, X; Connors, R; Johnstone, S; Cardozo, M; Cheng, AC; Jeffries, S; Franks, B; Li, S; Shen, S; Wong, M; Wesche, H; Xu, G; Carlson, TJ; Plant, M; Morgenstern, K; Rex, K; Schmitt, J; Coxon, A; Walker, N; Kayser, F; Wang, Z Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett23:4608-16 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 1 |
|---|
| Name: | Sphingosine kinase 1 |
|---|
| Synonyms: | SK 1 | SPHK1_MOUSE | SPK 1 | Sk1 | Sphk1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42447.37 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_107622 |
|---|
| Residue: | 382 |
|---|
| Sequence: | MEPVECPRGLLPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHA
RELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPGGSGNALAASV
NHYAGYEQVTNEDLLINCTLLLCRRRLSPMNLLSLHTASGLRLYSVLSLSWGFVADVDLE
SEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPVGTVASKRPASTLVQKGPVDTHLVPL
EEPVPSHWTVVPEQDFVLVLVLLHTHLSSELFAAPMGRCEAGVMHLFYVRAGVSRAALLR
LFLAMQKGKHMELDCPYLVHVPVVAFRLEPRSQRGVFSVDGELMVCEAVQGQVHPNYLWM
VCGSRDAPSGRDSRRGPPPEEP
|
|
|
|---|
| BDBM50438143 |
|---|
| n/a |
|---|
| Name | BDBM50438143 |
|---|
| Synonyms: | CHEMBL2409891 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26F3N3O2S |
|---|
| Mol. Mass. | 477.542 |
|---|
| SMILES | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(cs2)-c2ccc(cc2)C(F)(F)F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
