| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
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| Ligand | BDBM50438142 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972985 (CHEMBL2412223) |
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| IC50 | 40±n/a nM |
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| Citation |  Gustin, DJ; Li, Y; Brown, ML; Min, X; Schmitt, MJ; Wanska, M; Wang, X; Connors, R; Johnstone, S; Cardozo, M; Cheng, AC; Jeffries, S; Franks, B; Li, S; Shen, S; Wong, M; Wesche, H; Xu, G; Carlson, TJ; Plant, M; Morgenstern, K; Rex, K; Schmitt, J; Coxon, A; Walker, N; Kayser, F; Wang, Z Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett23:4608-16 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 2 |
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| Name: | Sphingosine kinase 2 |
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| Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
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| Type: | Protein |
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| Mol. Mass.: | 69221.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NRA0 |
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| Residue: | 654 |
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| Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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| BDBM50438142 |
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| n/a |
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| Name | BDBM50438142 |
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| Synonyms: | CHEMBL2409847 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25Cl2N3O2S |
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| Mol. Mass. | 478.435 |
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| SMILES | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2Cl)cc1 |r| |
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| Structure | 
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