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TargetSphingosine kinase 1
LigandBDBM50438152
Substrate/Competitorn/a
Meas. Tech.ChEMBL_972986 (CHEMBL2412224)
IC50 30±n/a nM
Citation Gustin, DJLi, YBrown, MLMin, XSchmitt, MJWanska, MWang, XConnors, RJohnstone, SCardozo, MCheng, ACJeffries, SFranks, BLi, SShen, SWong, MWesche, HXu, GCarlson, TJPlant, MMorgenstern, KRex, KSchmitt, JCoxon, AWalker, NKayser, FWang, Z Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett23:4608-16 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine kinase 1
Name:Sphingosine kinase 1
Synonyms:SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:Enzyme
Mol. Mass.:42521.16
Organism:Homo sapiens (Human)
Description:Q9NYA1
Residue:384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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  Blast E-value cutoff:
BDBM50438152
n/a
NameBDBM50438152
Synonyms:CHEMBL2409890
TypeSmall organic molecule
Emp. Form.C24H29N3O3S
Mol. Mass.439.57
SMILESCOc1ccc(cc1)-c1csc(Nc2ccc(CCN3CC[C@H](O)C[C@@H]3CO)cc2)n1 |r|
Structure
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