| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-5 [D153N] |
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| Ligand | BDBM32709 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_973058 (CHEMBL2412639) |
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| Ki | 4400±n/a nM |
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| Citation |  Tan, X; Furio, L; Reboud-Ravaux, M; Villoutreix, BO; Hovnanian, A; El Amri, C 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett23:4547-51 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-5 [D153N] |
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| Name: | Kallikrein-5 [D153N] |
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| Synonyms: | KLK-L2 | KLK5 | KLK5_HUMAN | Kallikrein 5 | Kallikrein-5 | Kallikrein-like protein 2 | SCTE | Stratum corneum tryptic enzyme |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32031.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1282456 |
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| Residue: | 293 |
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| Sequence: | MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARS
DDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGH
YSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNNLMLIKLNRRIRPTKDVRPINVSSHCPS
AGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDS
CQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
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| BDBM32709 |
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| n/a |
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| Name | BDBM32709 |
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| Synonyms: | (5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-methylphenyl)methanone | (5-azanyl-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-methylphenyl)methanone | 1-(4-methylbenzoyl)-3-(3-pyridinyl)-1H-1,2,4-triazol-5-amine | MLS000537840 | SMR000144080 | [5-amino-3-(3-pyridinyl)-1,2,4-triazol-1-yl]-(4-methylphenyl)methanone | [5-amino-3-(3-pyridyl)-1,2,4-triazol-1-yl]-(p-tolyl)methanone | cid_970375 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N5O |
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| Mol. Mass. | 279.2966 |
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| SMILES | Cc1ccc(cc1)C(=O)n1nc(nc1N)-c1cccnc1 |
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| Structure | 
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