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TargetHeme Oxygenase 1 (HO-1)
LigandBDBM50240895
Substrate/Competitorn/a
Meas. Tech.ChEMBL_976175
IC50 2500±n/a nM
Citation Salerno LPittalà VRomeo GModica MNSiracusa MADi Giacomo CAcquaviva RBarbagallo ITibullo DSorrenti V Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. Bioorg Med Chem 21:5145-53 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heme Oxygenase 1 (HO-1)
Name:Heme Oxygenase 1 (HO-1)
Synonyms:HSP32
Type:Enzyme
Mol. Mass.:33005.15
Organism:Rattus norvegicus (rat)
Description:HO-1 obtained from rat spleen was used in enzyme assays.
Residue:289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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  Blast E-value cutoff:
BDBM50240895
n/a
NameBDBM50240895
Synonyms:2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | CHEMBL162549
TypeSmall organic molecule
Emp. Form.C11H9N3O3
Mol. Mass.231.2075
SMILES[O-][N+](=O)c1ccc(cc1)C(=O)Cn1ccnc1
Structure
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