| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50438698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_976373 (CHEMBL2415509) |
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| IC50 | 6750±n/a nM |
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| Citation |  Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM50438698 |
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| n/a |
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| Name | BDBM50438698 |
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| Synonyms: | CHEMBL2414663 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N7O4 |
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| Mol. Mass. | 435.4359 |
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| SMILES | Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3cnon3)C(=O)c12 |
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| Structure | 
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