Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50438725 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_976373 (CHEMBL2415509) | ||
IC50 | 110±n/a nM | ||
Citation | Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
| ||
BDBM50438725 | |||
n/a | |||
Name | BDBM50438725 | ||
Synonyms: | CHEMBL2414652 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H31N5O3 | ||
Mol. Mass. | 449.5453 | ||
SMILES | Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCCC4)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(21.03,-46.19,;21.01,-47.73,;19.67,-48.48,;19.65,-50.03,;20.99,-50.81,;22.33,-50.05,;23.52,-51.03,;25.04,-50.71,;25.72,-49.32,;25.04,-47.91,;26.04,-46.71,;27.54,-46.96,;28.51,-45.79,;27.97,-44.32,;26.48,-44.11,;25.51,-45.28,;28.96,-43.12,;28.43,-41.7,;29.4,-40.52,;30.9,-40.74,;31.88,-39.55,;33.4,-39.81,;33.94,-41.25,;34.39,-38.62,;35.93,-38.71,;36.51,-37.26,;35.31,-36.27,;34,-37.1,;31.44,-42.2,;30.46,-43.38,;23.56,-47.57,;23.23,-46.06,;22.34,-48.52,)| | ||
Structure |