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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50438726 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_976373 (CHEMBL2415509) | ||
| IC50 | 99±n/a nM | ||
| Citation |  Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50438726 | |||
| n/a | |||
| Name | BDBM50438726 | ||
| Synonyms: | CHEMBL2414684 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25N3O4 | ||
| Mol. Mass. | 395.4516 | ||
| SMILES | Nc1ccnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(25.66,-48.71,;25.59,-50.24,;24.22,-50.95,;24.14,-52.49,;25.45,-53.32,;26.82,-52.61,;27.98,-53.64,;29.5,-53.36,;30.23,-52,;29.61,-50.57,;30.65,-49.4,;32.14,-49.71,;33.15,-48.57,;32.66,-47.09,;31.18,-46.82,;30.16,-47.95,;33.7,-45.92,;33.22,-44.48,;34.23,-43.34,;35.72,-43.61,;36.75,-42.46,;38.25,-42.77,;39.29,-41.61,;38.74,-44.22,;36.2,-45.09,;35.19,-46.23,;28.14,-50.17,;27.87,-48.65,;26.89,-51.08,)| | ||
| Structure | 
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