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TargetDiacylglycerol O-acyltransferase 1 (DGAT1)
LigandBDBM50438736
Substrate/Competitorn/a
Meas. Tech.ChEMBL_976373
IC50 44±n/a nM
Citation Dow RLAndrews MPLi JCMichael Gibbs EGuzman-Perez ALaperle JLLi QMather DMunchhof MJNiosi MPatel LPerreault CTapley SZavadoski WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem 21:5081-97 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1 (DGAT1)
Name:Diacylglycerol O-acyltransferase 1 (DGAT1)
Synonyms:ACAT-related gene product 1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50438736
n/a
NameBDBM50438736
Synonyms:CHEMBL2414678
TypeSmall organic molecule
Emp. Form.C22H26N4O4
Mol. Mass.410.4662
SMILESCc1nc(N)c2c(OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C2=O)n1 |r,wU:17.17,wD:20.21,(19.91,-46.4,;21.27,-45.67,;21.32,-44.12,;22.68,-43.39,;22.73,-41.85,;23.99,-44.21,;23.95,-45.74,;25.12,-46.75,;26.64,-46.45,;27.35,-45.08,;26.71,-43.66,;27.73,-42.47,;29.23,-42.76,;30.23,-41.6,;29.71,-40.12,;28.22,-39.87,;27.23,-41.03,;30.73,-38.94,;30.23,-37.5,;31.23,-36.34,;32.72,-36.6,;33.73,-35.42,;35.24,-35.71,;35.75,-37.16,;36.26,-34.54,;33.23,-38.06,;32.23,-39.22,;25.23,-43.28,;24.94,-41.76,;22.58,-46.48,)|
Structure
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