Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Sterol O-acyltransferase 1 | ||
Ligand | BDBM50438735 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_976300 (CHEMBL2415208) | ||
IC50 | >10000±n/a nM | ||
Citation | Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sterol O-acyltransferase 1 | |||
Name: | Sterol O-acyltransferase 1 | ||
Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT | ||
Type: | Multi-pass membrane protein may form homo- or heterodimers. | ||
Mol. Mass.: | 64751.94 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35610 | ||
Residue: | 550 | ||
Sequence: |
| ||
BDBM50438735 | |||
n/a | |||
Name | BDBM50438735 | ||
Synonyms: | CHEMBL2414670 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H26N6O3 | ||
Mol. Mass. | 434.4909 | ||
SMILES | Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1 |r,wU:9.12,wD:6.5,(36.55,-43.27,;35.45,-42.18,;35.71,-40.66,;34.32,-39.96,;33.22,-41.07,;31.72,-40.82,;30.73,-42.03,;29.22,-41.78,;28.26,-42.96,;28.81,-44.42,;30.3,-44.64,;31.27,-43.46,;27.82,-45.63,;26.31,-45.38,;25.34,-46.57,;25.88,-48.02,;27.38,-48.24,;28.35,-47.06,;24.9,-49.22,;25.54,-50.6,;24.91,-52.01,;23.38,-52.34,;22.18,-51.36,;20.84,-52.13,;19.5,-51.35,;19.51,-49.8,;20.86,-49.04,;20.86,-47.5,;22.19,-49.82,;23.4,-48.87,;23.07,-47.35,;33.93,-42.42,)| | ||
Structure |