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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50438733 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_976373 (CHEMBL2415509) | ||
| IC50 | 41±n/a nM | ||
| Citation |  Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50438733 | |||
| n/a | |||
| Name | BDBM50438733 | ||
| Synonyms: | CHEMBL2414667 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23N5O2 | ||
| Mol. Mass. | 377.4396 | ||
| SMILES | Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC#N)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(28.43,-50.53,;28.37,-52.07,;27.01,-52.81,;26.96,-54.35,;28.27,-55.17,;29.63,-54.44,;30.8,-55.45,;32.31,-55.15,;33.03,-53.79,;32.4,-52.36,;33.42,-51.18,;34.91,-51.47,;35.91,-50.32,;35.41,-48.84,;33.93,-48.59,;32.93,-49.74,;36.43,-47.66,;35.94,-46.22,;36.94,-45.07,;38.43,-45.32,;39.44,-44.16,;40.96,-44.45,;42.47,-44.74,;38.94,-46.8,;37.93,-47.95,;30.93,-51.98,;30.63,-50.46,;29.68,-52.89,)| | ||
| Structure | 
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