Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50438731 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_976374 (CHEMBL2415510) | ||
IC50 | 40±n/a nM | ||
Citation | Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50438731 | |||
n/a | |||
Name | BDBM50438731 | ||
Synonyms: | CHEMBL2414669 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H31N5O2 | ||
Mol. Mass. | 409.5245 | ||
SMILES | CC(C)(N)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:8.11,wD:5.4,(38.06,-43.71,;37.56,-42.25,;38.58,-41.09,;39.04,-42.64,;36.07,-41.95,;35.03,-43.12,;33.53,-42.83,;32.52,-43.97,;33.02,-45.46,;34.51,-45.72,;35.52,-44.57,;31.99,-46.63,;30.49,-46.33,;29.47,-47.49,;29.97,-48.96,;31.47,-49.23,;32.48,-48.08,;28.95,-50.12,;29.57,-51.55,;28.84,-52.91,;27.32,-53.2,;26.15,-52.17,;24.77,-52.9,;23.47,-52.08,;23.53,-50.52,;24.9,-49.81,;24.96,-48.26,;26.21,-50.64,;27.46,-49.72,;27.18,-48.2,)| | ||
Structure |