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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50438730
Substrate/Competitorn/a
Meas. Tech.ChEMBL_976374 (CHEMBL2415510)
IC50 37±n/a nM
Citation Dow, RLAndrews, MPLi, JCMichael Gibbs, EGuzman-Perez, ALaperle, JLLi, QMather, DMunchhof, MJNiosi, MPatel, LPerreault, CTapley, SZavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50438730
n/a
NameBDBM50438730
Synonyms:CHEMBL2414675
TypeSmall organic molecule
Emp. Form.C24H28N6O3
Mol. Mass.448.5175
SMILESCc1noc(CC[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1 |r,wU:10.13,wD:7.6,(40.74,-42.42,;39.26,-42.85,;38.05,-41.9,;36.77,-42.77,;37.22,-44.27,;36.25,-45.5,;34.74,-45.28,;33.77,-46.51,;32.26,-46.28,;31.32,-47.48,;31.9,-48.94,;33.39,-49.12,;34.34,-47.92,;30.94,-50.16,;29.42,-49.94,;28.48,-51.14,;29.05,-52.58,;30.56,-52.78,;31.5,-51.58,;28.09,-53.79,;28.79,-55.18,;28.14,-56.58,;26.64,-56.95,;25.42,-55.99,;24.09,-56.78,;22.74,-56.03,;22.72,-54.49,;24.05,-53.7,;24.03,-52.16,;25.4,-54.45,;26.59,-53.47,;26.22,-51.97,;38.74,-44.3,)|
Structure
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