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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50438744 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_976373 (CHEMBL2415509) | ||
| IC50 | 34±n/a nM | ||
| Citation |  Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50438744 | |||
| n/a | |||
| Name | BDBM50438744 | ||
| Synonyms: | CHEMBL2414700 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25N5O3 | ||
| Mol. Mass. | 395.4549 | ||
| SMILES | NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:7.10,wD:4.3,(38.2,-37.65,;37.22,-38.85,;37.76,-40.29,;35.69,-38.61,;34.72,-39.81,;33.22,-39.6,;32.26,-40.78,;32.8,-42.2,;34.3,-42.45,;35.27,-41.26,;31.81,-43.41,;32.37,-44.88,;31.41,-46.06,;29.91,-45.81,;29.36,-44.39,;30.32,-43.21,;28.92,-47.03,;29.6,-48.43,;28.93,-49.82,;27.42,-50.17,;26.22,-49.19,;24.88,-49.96,;23.54,-49.18,;23.55,-47.64,;24.88,-46.88,;24.89,-45.33,;26.22,-47.65,;27.43,-46.69,;27.09,-45.19,)| | ||
| Structure | 
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